Central Dogma
NOTE: Lifted from the site of Sir Baggy .
The Central Dogma of Molecular Genetics
The Central Dogma of Molecular Genetics provides the information on how DNA controls the expression of certain hereditary traits in a form of proteins. Conventionally, the flow of information from DNA to proteins is simplistic, i.e. from DNA to RNA to proteins. However, current studies reported several special cases where the information is reverted back to DNA from RNA, the process of which is known as reverse transcription. This special case is known to occur in retroviruses such as the human immunovirus (HIV), as well as in eukaryotes such as the case of retrotransposons and telomere synthesis.
In this module, you will study the general and special cases of information transfer. You will explore how the information stored in the blueprint is being replicated, transcribed, and translated into proteins.
Below is the list of topics that you will study in this module. Click on each topic or link to access or download the resource materials.
1.The Central Dogma
2.Variations from the General Central Dogma
■ Cells may stray from Central Dogma
■ DNA sequence may be lost in translation
3.The Genetic Code
4.DNA Transcription
5.DNA Translation
6.DNA and Diseases
■ DNA Deletion and Duplication
■ Copy Number Variation and Genetic Disease
ACTIVITY
1. To allow you to experience how DNA information is decoded during protein synthesis, you may try to play the interactive transcription and translation of a gene activity. The activity can be accessed by clicking on this link. Be sure to remember the principles behind the processes in the activity. Don't forget to read the instruction below the game board. Enjoy playing.
2. Watch the video clip below. This material visualizes the principle of the Central Dogma of Molecular Genetics. Take note how the genetic information stored in DNA is being decoded through the processes of replication, transcription, and translation. No wonder why DNA is considered as the blueprint of heredity. Another video shows the process of reverse transcription, which is observed in retroviruses. Take note why it is called "reverse transcription." Enjoy watching.
Video 1
Video 2
The Central Dogma of Molecular Genetics
The Central Dogma of Molecular Genetics provides the information on how DNA controls the expression of certain hereditary traits in a form of proteins. Conventionally, the flow of information from DNA to proteins is simplistic, i.e. from DNA to RNA to proteins. However, current studies reported several special cases where the information is reverted back to DNA from RNA, the process of which is known as reverse transcription. This special case is known to occur in retroviruses such as the human immunovirus (HIV), as well as in eukaryotes such as the case of retrotransposons and telomere synthesis.
In this module, you will study the general and special cases of information transfer. You will explore how the information stored in the blueprint is being replicated, transcribed, and translated into proteins.
Below is the list of topics that you will study in this module. Click on each topic or link to access or download the resource materials.
1.The Central Dogma
2.Variations from the General Central Dogma
■ Cells may stray from Central Dogma
■ DNA sequence may be lost in translation
3.The Genetic Code
4.DNA Transcription
5.DNA Translation
6.DNA and Diseases
■ DNA Deletion and Duplication
■ Copy Number Variation and Genetic Disease
ACTIVITY
1. To allow you to experience how DNA information is decoded during protein synthesis, you may try to play the interactive transcription and translation of a gene activity. The activity can be accessed by clicking on this link. Be sure to remember the principles behind the processes in the activity. Don't forget to read the instruction below the game board. Enjoy playing.
2. Watch the video clip below. This material visualizes the principle of the Central Dogma of Molecular Genetics. Take note how the genetic information stored in DNA is being decoded through the processes of replication, transcription, and translation. No wonder why DNA is considered as the blueprint of heredity. Another video shows the process of reverse transcription, which is observed in retroviruses. Take note why it is called "reverse transcription." Enjoy watching.
Video 1
Video 2
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