A Potential Replacement for Embryonic Stem Cells
Synopsis: Epigenetics is the science of altering gene function without altering DNA. In this report, scientists found out that mature fibroblasts (connective tissue cells) can be reprogrammed to produce induced pluripotent stem cells (iPSC), a stem cell that is different from the normal stem cells (undifferentiated) produced during embryonic development. Through the process of methylation (silencing of the genes), the epigenetic characteristic of an iPSC was determined and compared to the methylation patterns of the cell from which it was extracted. DMR (differentially methylated regions) comparisons showed surprising overlaps between DMRs of stem cells from fibroblast and DMRs of normal cells that turn into cancer cells. As compared to the embryonic stem cells which are now used for treatments and therapies, the methylation patterns of iPSC could be a potential area for development of new approaches in stem cell therapy, using iPSC as a replacement for embryonic stem cells. Scientist...